导师信息#中国药科大学药学院研究生导师介绍#胡庆华

13667188015

胡庆华，男，副教授，中国药科大学药理教研室。2002-2006年在南京大学匡亚明学院基础学科教学强化部学习获学士学位；2006-2011年在南京大学硕博连读并获博士学位，研究方向为代谢性疾病药理。目前主持国家自然科学基金青年项目1项（NSFC81202573）和中央高校基本科研业务业务费培育项目1项，参与国家自然科学基金项目1项（NSCF81373419），曾参与国家杰出青年项目1项（NSFC81025025）、国家自然科学基金（NSFC81025025，NSFC30873413）和江苏省自然科学基金（BK2010365，BK2007143）各2项，作为参研人员参与数项科研及新药前期研究项目。截至目前，已发表中、英文学术论文共篇18篇（SCI收录13篇，EI收录1篇，国内核心期刊4篇），其中第一作者或通讯作者论文12篇；作为第三发明人申请发明专利1项并获得授权。
电话：13770837347,EMAIL：huqh@cpu.edu.cn
·Hu, Q. H., Wei, B., Wei, L., Hua, K., Yu, X., Li, H., Ji, H. Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome. Int J Cardiol 196, 183-192 (2015).·Li, Q., Hu, Q. H., Wang, X., Zong, Y., Zhao, L., Xing, J., Zhou, J., Zhang, H. Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents. Chem Biol Drug Des [Epub ahead of print] (2015). (共同一作)·Hu, Q. H., Zhu, J. X., Ji, J., Wei, L. L., Miao, M. X., Ji, H. Fructus Gardenia Extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3. Molecules 18 (8), 8976-8993 (2013).·Xu, Y. Y., Li, S. N., Yu, G. J., Hu, Q. H., Li, H. Q. Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity. Bioorg Med Chem, 21, 6084-6091 (2013). (通讯作者)·Chen, Y. S., Hu, Q. H., Zhang, X., Kong, L. D. Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. Pharmacology 92, 75-83 (2013). (共同一作)·Hu, Q. H., Zhang, X., Pan, Y., Li, Y. C., Kong, L. D. Allopurinol, rutin, and quercetin ameliorate NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats. Biochem pharmacol 84 (1), 113-125 (2012).·Hu, Q.H., Zhang, X., Wang, X., Jiao, R. Q., Kong, L. D. Quercetin regulates the expression of organic ion transporters and uromodulin and reduces renal damage in hyperuricemic mice. Eur J Nutr 51 (5), 593-606(2012).·Hu, Q. H., Wang, C., Li, J. M., Zhang, D. M., Kong, L. D. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. Am J Physiol Renal Physiol 297 (4), 1080-1091 (2009).·Hu, Q.H., Jiao, R. Q., Wang, X., Lv, Y. Z., Kong, L. D. Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice. J Ethnopharmacol 128 (3), 685-692 (2010).·Hu, Q. H., Zhang, X., Wang, X., Kong, L. D. Magiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuicemic mice.Acta Pharmaceutica Sinica 45 (10), 1239-1247 (2010).·胡庆华, 缪明星, 卢国, 季晖. 槲皮素对尿酸性肾病大鼠肾脏NLRP3和TLRs表达的影响. 中草药 44 (24), 3496-3502 (2013).·胡庆华, 朱继孝, 李宁, 缪明星. 栀子苷对氧嗪酸钾盐致小鼠高尿酸血症的作用及其机制研究. 中南药学 11 (10), 721-725 (2013).·Li, J. M., Li, Y. C., Kong, L. D., Hu, Q. H. Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology51 (5), 1555-1566 (2010).·Li, J. M., Wang, W., Fan, CF., Wang, MX., Zhang, X., Hu, Q. H., Kong, L. D. Quercetin preserves ?-cell mass and function in fructose-induced Hyperinsulinemia through modulating Pancreatic Akt/FoxO1 Activation. Evid Based Complement Alternat Med 2013, 303902. (2013).·Wang, X., Wang, C. P., Hu, Q. H., Lv, Y. Z., Zhang, X., Ouyang, Z., Kong, L. D. The dual actions of Sanmiao wan as a hypouricemic agent: down-regulation of hepatic XOD and renal mURAT1 in hyperuricemic mice. J Ethnopharmacol128 (1), 107-115 (2010).·Mo, S. F., Zhou, F., Lv, Y. Z., Hu, Q. H., Zhang, D. M., Kong, L. D. Hypouricemic action of selected flavonoids in mice: structure-activity relationships.Biol Pharm Bull30 (8), 1551-1556 (2007).·吕耀中, 胡庆华, 王星, 欧阳臻, 孔令东. 二妙丸水提取物对高尿酸血症小鼠尿酸失衡及其相关基因和蛋白水平的影响. 中草药 3, 418-423 (2010).·李建梅, 王闯, 胡庆华, 孔令东. 果糖引起大鼠瘦素功能失调及槲皮素和芦丁的改善作用. 中国天然药物 6, 466-473 (2010).·孔令东, 潘颖, 胡庆华等. CN200710190133.X 槐米黄酮提取物在制备尿酸转运子URAT1抑制药物中的应用.