导师信息#兰州大学药学院导师介绍#王少华

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姓名：王少华 ( 男 )职称职务：副教授电子邮箱：wangshh@lzu.edu.cn
学习与工作经历
1997年9月-2001年6月 兰州大学，化学化工学院化学专业，获学士学位；2001年9月-2006年6月 兰州大学，化学化工学院有机化学专业，博士学位，导师：涂永强院士2006年7月-2011年8月 MayoClinic，Department of Molecular Pharmacology & Experimental Therapeutics，高级研究助理2011年8月-今 兰州大学，药学院，副教授
教学工作与成果
负责本科生《分析化学》和 研究生 《专业外语》的教学工作。
科研项目与成果
1. Yong-Qiang Zhang, Dao-Yong Zhu, Bao-Sheng Li, Yong-Qiang Tu,* Ji-Xing Liu, Yong Lu，Shao-Hua Wang*Palladium-Catalyzed Cascade Process to Construct 2, 5-Disubstituted PyrrolesSubmitted2. Yuan-Ping Pang,* J. G. Park, Shao-Hua Wang, A. Vummenthala, R. K. Mishra, J. E. McLaughlin, R. Di, J. N. Kahn, N. E. Tumer, L. Janosi, J. Davis, C. B. Millard.Small Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Door-stop Approach.PLoS ONE, 2011, 6, e17883.3. Yuan-Ping Pang,* J. Davis,* Shao-Hua Wang, J. G. Park, M. P. Nambiar, James J. Schmidt, C. B. Millard.Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A.PLoS ONE, 2010, 5, e10129.4. Yuan-Ping Pang,* A. Vummenthala, R. K. Mishra, J. G. Park, Shao-Hua Wang, J. Davis, C. B. Millard, James J. Schmidt.Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design.PLoS ONE, 2009, 4, e7730.5. Jian-Dong Liu, Shao-Hua Wang, Fu-Min Zhang, Yong-Qiang Tu,* Yong-Qiang Zhang.Concise Total Synthesis of (±)-Crinine.Synlett, 2009, 12, 3040-3042.6. Fu-Min Zhang, Yong-Qiang Tu,* Jian-Dong Liu, Xiao-Hui Fan, Lei Shi, Xiang-Dong Hu, Shao-Hua Wang, Yong-Qiang Zhang.A general approach to crinine-type Amaryllidaceae alkaloids: total syntheses of (±)-haemanthidine, (±)-pretazettine, (±)-tazettine, and (±)-crinamine.Tetrahedron, 2006, 62, 9446-9455.7. Shao-Hua Wang, Yong-Qiang Tu,* Min Wang.t-BuOK promoted coupling of alkynes and aldehydes: a concise synthetic method of beta,gamma-unsaturated enones.Tetrahedron Lett., 2006, 47, 8621-8623.8. Shao-Hua Wang, Yong-Qiang Tu,* Pen Chen, Xiang-Dong Hu, Fu-Min Zhang, Ai-Xia Wang.KOtBu-promoted three-component coupling of aldehydes and alkynes: Highly efficient synthesis of 1-En-4-yn-3-ols and 2-En-4-yn-1-ols.J. Org. Chem., 2006, 71, 4343-4345.9. Shao-Hua Wang, Yong-Qiang Tu,* Pen Chen.Enantioselective addition of phenylacetylene to ketones catalyzed by titanium(IV) complexes of N-sulfonylated beta-amino alcohols.Chinese J. Chem., 2006, 24, 165-168.10. Ai-Xia Wang, Yong-Qiang Tu,* Zhen-Lei Song, Dao-Yi Yuan, Xiang-Dong Hu, Shao-Hua Wang, Shuan-Hu Gao.Synthetically useful Wagner-Meerwein rearrangement of alpha-quaternary beta-bromovinyl methyl ethers.Eur. J. Org. Chem., 2006, 12, 2691-2694.11. Xiang-Dong Hu, Yong-Qiang Tu,* En Zhang, Shuan-Hu Gao, Shao-Hua Wang, Ai-Xia Wang, Chun-An Fan, Min Wang.Total synthesis of (±)-galanthamine.Org. Lett., 2006, 8, 1823-1825.12. Shuan-Hu Gao, Yong-Qiang Tu,* Xiang-Dong Hu, Shao-Hua Wang, Rong-Bao Hua, Yi-Jun Jiang, Yu-Ming Zhao, Xiao-Hui Fan, Shu-Yu Zhang.General and efficient strategy for erythrinan and homoerythrinan alkaloids: Syntheses of (±)-3-demethoxyerythratidinone and (±)-erysotramidine.Org. Lett., 2006, 8, 2373-2376.13. Shao-Hua Wang, Fei Wang, Fu-Min Zhang, Chun-An Fan, Yong-Qiang Tu,* Shi-Kuo Ren.Kinetic resolution of beta-hydroxy epoxides promoted by chiral aluminium reagents.Chinese J. Org. Chem., 2005, 25, 1302-1305.14. Min Wang, Bao-Min Wang, Lei Shi, Yong-Qiang Tu,* Chun-An Fan, Shao-Hua Wang, Xiang-Dong Hu, Shu-Yu Zhang.Quinine/selectfluor combination induced asymmetric semipinacol rearrangement of allylic alcohols: an effective and enantioselective approach to alpha-quaternary beta-fluoro aldehydes.Chem. Commun., 2005, 5580-5582.15. Pei-Nian Liu, Jin-Gen Deng, Yong-Qiang Tu,* Shao-Hua Wang.Highly efficient and recyclable heterogeneous asymmetric transfer hydrogenation of ketones in water.Chem. Commun., 2004, 2070-2071.16. Xue-Qiang Li, Hong Wang, Yong-Qiang Tu,* Shao-Hua Wang.Synthetic studies of the HIV- inhibitive marine natural products synthesis of the C1 similar to C7 fragment of didemnaketal A.Acta Chim. Sinica, 2004, 62, 839-841, (2004)17. Fei Wang, Shao-Hua Wang, Yong-Qiang Tu,* Shi-Kuo Ren.AlEt3-promoted eliminative ring-opening of beta-hydroxy epoxides: highly stereoselective synthesis of terminal alpha-hydroxy olefins.Tetrahedron-Asymmetry, 2003, 14, 2189-2193.18. Fei Wang, Yong-Qiang Tu,* Chun-An Fan, Shao-Hua Wang, Fu-Min Zhang.Kinetic resolution via semipinacol rearrangement of alpha-hydroxy epoxides: a new method for asymmetric synthesis of alpha-hydroxy epoxides and beta-hydroxy ketones containing an alpha-quaternary carbon.Tetrahedron-Asymmetry, 2002, 13, 395-298.
研究与招生方向
有机合成方法学和天然产物全合成具有生物（药物）活性的小分子的设计与合成高通量小分子活性测定方法的设计